Search Result

Results for "

AMPK Activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (94) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (2) AP-1 (1) Apoptosis (10) ATP Citrate Lyase (3) Autophagy (18) Bacterial (5) Bcl-2 Family (3) Beclin1 (2) Calcium Channel (4) Cannabinoid Receptor (1) Caspase (1) Chloride Channel (3) COX (3) E1/E2/E3 Enzyme (1) Endogenous Metabolite (4) ERK (1) Fungal (2) GLUT (1) HDAC (2) HSP (1) Isotope-Labeled Compounds (6) JNK (1) Keap1-Nrf2 (2) Mitochondrial Metabolism (3) Mitophagy (7) mTOR (3) NF-κB (3) NO Synthase (1) Nuclear Hormone Receptor 4A/NR4A (1) Organoid (2) Oxidative Phosphorylation (3) Parasite (4) Potassium Channel (3) PPAR (1) Reactive Oxygen Species (3) Salt-inducible Kinase (SIK) (2) Sirtuin (1) STAT (2) TGF-β Receptor (3) Tyrosinase (1) Virus Protease (1) YAP (2) β-catenin (1)
By Research Areas:	Cancer (44) Cardiovascular Disease (12) Infection (7) Inflammation/Immunology (12) Metabolic Disease (61) Neurological Disease (5)

By Targets:

AMPK (94)

Adenosine Receptor (1)

Adrenergic Receptor (1)

Akt (2)

AP-1 (1)

Apoptosis (10)

ATP Citrate Lyase (3)

Autophagy (18)

Bacterial (5)

Bcl-2 Family (3)

Beclin1 (2)

Calcium Channel (4)

Cannabinoid Receptor (1)

Caspase (1)

Chloride Channel (3)

COX (3)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (4)

ERK (1)

Fungal (2)

GLUT (1)

HDAC (2)

HSP (1)

Isotope-Labeled Compounds (6)

JNK (1)

Keap1-Nrf2 (2)

Mitochondrial Metabolism (3)

Mitophagy (7)

mTOR (3)

NF-κB (3)

NO Synthase (1)

Nuclear Hormone Receptor 4A/NR4A (1)

Organoid (2)

Oxidative Phosphorylation (3)

Parasite (4)

Potassium Channel (3)

PPAR (1)

Reactive Oxygen Species (3)

Salt-inducible Kinase (SIK) (2)

Sirtuin (1)

STAT (2)

TGF-β Receptor (3)

Tyrosinase (1)

Virus Protease (1)

YAP (2)

β-catenin (1)

By Research Areas:

Cancer (44)

Cardiovascular Disease (12)

Infection (7)

Inflammation/Immunology (12)

Metabolic Disease (61)

Neurological Disease (5)

111

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: AMPK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155363

AMPK activator 13	AMPK	Metabolic Disease
AMPK activator 13 is a potent activator of *AMPK. AMPK* activator 13 inhibits mitotic clonal expansion of 3T3-L1 cells by activating AMPK pathway and enhances cell mitochondrial oxygen consumption rate. AMPK activator 13 can be used in study obesity .

HY-131334

AMPK activator 4	AMPK	Metabolic Disease
AMPK activator 4 is a potent *AMPK* activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect .

HY-154973

AMPK activator 11	Oxidative Phosphorylation Mitochondrial Metabolism AMPK	Metabolic Disease Cancer
AMPK activator 11 is an AMP-activated protein kinase (AMPK) activator with nanomolelevel antiproliferation activities against several CRCs. AMPK activator 11 selectively inhibits the RKO xenograft growth along by activating AMPK and upregulating oxidative phosphorylation (OXPHOS) ( mitochondrial metabolism ) and can be used for anti-tumor and metabolic disease research .

HY-147037

AMPK activator 7	AMPK	Cardiovascular Disease Metabolic Disease
AMPK activator 7 (compound I-3-24) is a an *AMPK* activator with the EC₅₀ of 8.8 nM. AMPK activator 7 can be used for the research of diseases involving AMPK, particularly diseases such as type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia and/or hypertension .

HY-148684

AMPK activator 10	AMPK	Metabolic Disease
AMPK activator 10 is an orally active, potent *AMPK* activator with EC₁₅₀ of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect .

HY-149406

AMPK activator 12

AMPK Cancer

AMPK activator 12 (compound 21) is a potent AMPK activator and GDF15 inducer. AMPK activator 12 increases GDF15 protein levels in human hepatic cells .

AMPK activator 12	AMPK	Cancer
AMPK activator 12 (compound 21) is a potent *AMPK* activator and GDF15 inducer. AMPK activator 12 increases GDF15 protein levels in human hepatic cells .

HY-162042

AMPK activator 14	AMPK	Metabolic Disease
AMPK activator 14 (compound 32) is an orally active *AMPK* activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes .

HY-148210

AMPK activator 9	AMPK	Metabolic Disease
AMPK activator 9 (ZM-6) is a potent AMPK (α2β1γ1) activator with an EC₅₀ value of 1.1 µM. AMPK activator 9 has the potential for the research of type 2 diabetes .

HY-146398

AMPK activator 6	AMPK	Metabolic Disease
AMPK activator 6 (Compound GC) reduces lipid content and activates the AMPK pathway in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase in triglyceride (TG) , total cholesterol (TC), low-density lipoprotein-C (LDL-C), and other biochemical indices in blood serum. AMPK activator 6 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome .

HY-U00292

AMPK activator 1

AMPK Metabolic Disease

AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1, compound No.1-75, has an EC₅₀ of <0.1μM.

AMPK activator 1	AMPK	Metabolic Disease
AMPK activator 1 is an *AMPK* activator extracted from patent WO2013116491A1, compound No.1-75, has an EC₅₀ of <0.1μM.

HY-130723

AMPK activator 2	AMPK	Cancer
AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates *AMPK* signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-130723A

AMPK activator 2 hydrochloride	AMPK	Cancer
AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates *AMPK* signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-147038

AMPK activator 8	AMPK	Metabolic Disease
AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC₅₀s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes .

HY-157129

AMPK-α1β1γ1 activator 1	AMPK	Cardiovascular Disease
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC₅₀ value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy .

HY-N11924

Foenumoside B	AMPK PPAR	Metabolic Disease
Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum. Foenumoside B activates *AMPK* signaling, inhibits PPARγ-induced adipogenesis, and shifts lipid metabolism toward lipolysis. Foenumoside B can be used in the study of obesity and obesity-related metabolic diseases .

HY-A0144A

Etilefrine hydrochloride	AMPK Adrenergic Receptor	Cardiovascular Disease
Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an *AMPK* activator. Etilefrine hydrochloride can be used for the research of postural hypotension .

HY-N6077

Thalidezine	Others	Cancer
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .

HY-160004

PXL770

AMPK Others

PXL770 is a direct AMP kinase activator. PXL770 can be used in the research of non-alcoholic fatty liver disease (NAFLD) .
HY-103239

PT1

AMPK Cardiovascular Disease Metabolic Disease

PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers .
HY-12831

Ampkinone

3 Publications Verification

AMPK Metabolic Disease

Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.

PXL770	AMPK	Others
PXL770 is a direct AMP kinase activator. PXL770 can be used in the research of non-alcoholic fatty liver disease (NAFLD) .

PT1	AMPK	Cardiovascular Disease Metabolic Disease
PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers .

Ampkinone 3 Publications Verification	AMPK	Metabolic Disease
Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.

HY-117755

PF-739	AMPK	Metabolic Disease
PF-739 is an orally active and non-selective activator of *AMPK. PF-739 activates* 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes .

HY-16708A

ZLN024 hydrochloride 1 Publications Verification	AMPK	Metabolic Disease
ZLN024 hydrochloride is an *AMPK* allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC₅₀s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.

HY-16708

ZLN024	AMPK	Metabolic Disease
ZLN024 is an *AMPK* allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC₅₀s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.

HY-N6913

3α-Hydroxymogrol	AMPK	Metabolic Disease
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent *AMPK* activator, and enhances AMPK phosphorylation .

HY-111363

MK8722

5+ Cited Publications

AMPK Metabolic Disease

MK8722 is a potent and systemic pan-AMPK activator.
HY-107988

MK-3903

2 Publications Verification

AMPK Metabolic Disease

MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC₅₀ of 8 nM.

MK8722 5+ Cited Publications	AMPK	Metabolic Disease
MK8722 is a potent and systemic *pan-AMPK* activator.

MK-3903 2 Publications Verification	AMPK	Metabolic Disease
MK-3903 is a potent and selective *AMP-activated* protein kinase** (AMPK) activator with an EC₅₀ of 8 nM.

HY-N6631

7-Methoxyisoflavone 2 Publications Verification	AMPK	Metabolic Disease Cancer
7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).

HY-120904

AMPK-IN-1

AMPK Metabolic Disease

AMPK-IN-1 is an activator of AMPK (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .
HY-P0136

SAMS

2 Publications Verification

AMPK Metabolic Disease

SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
HY-50662

A-769662

25+ Cited Publications

AMPK Cancer

A-769662 is a potent, reversible AMPK activator with EC₅₀ of 0.8 μM.

AMPK-IN-1	AMPK	Metabolic Disease
AMPK-IN-1 is an activator of *AMPK* (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .

SAMS 2 Publications Verification	AMPK	Metabolic Disease
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

A-769662 25+ Cited Publications	AMPK	Cancer
A-769662 is a potent, reversible *AMPK* activator with EC₅₀ of 0.8 μM.

HY-16397A

Phenformin hydrochloride 5+ Cited Publications Phenethylbiguanide hydrochloride	AMPK Autophagy	Cancer
Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate *AMPK* activity.

HY-120270

PF-06679142	AMPK	Metabolic Disease
PF-06679142 (Compound 10) is a potent, orally active *AMPK* activator with an EC₅₀ of 22 nM against *α1β1γ1-AMPK*. PF-06679142 can be used for diabetic nephropathy research .

HY-12357S2

Bempedoic acid-d4 ETC-1002-d₄; ESP-55016-d₄	ATP Citrate Lyase AMPK	Others
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

HY-155967

CB1R/AMPK modulator 1	AMPK Cannabinoid Receptor	Metabolic Disease
CB1R/AMPK modulator 1 (Compound 38-S) is an orally active *CB1R/AMPK* modulator, with an K_i of 0.81 nM and an IC₅₀ of 3.9 nM for CB1R. CB1R/AMPK modulator 1 activates AMPK. CB1R/AMPK modulator 1 reduces food intake and body weight, and improves glucose tolerance and insulin sensitivity .

HY-N2312

Mogrol 1 Publications Verification	ERK STAT	Cancer
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating *AMPK* signaling.

HY-15840

YLF-466D

2 Publications Verification

C24
AMPK Cancer

YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.
HY-N3425

Kazinol U

AMPK Others

Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

YLF-466D 2 Publications Verification C24	AMPK	Cancer
YLF-466D is a newly developed *AMPK* activator, which inhibits platelet aggregation.

Kazinol U	AMPK	Others
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-P1576A

AMARA peptide TFA	Salt-inducible Kinase (SIK) AMPK	Others
AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK).

HY-N6971

Cimiracemoside C

Cimicifugoside M
AMPK Metabolic Disease

Cimiracemoside C is an active component of Cimicifuga racemosa, activates AMPK, has the potential activity against diabetes .

Cimiracemoside C Cimicifugoside M	AMPK	Metabolic Disease
Cimiracemoside C is an active component of Cimicifuga racemosa, activates *AMPK*, has the potential activity against diabetes .

HY-124822

COH-SR4 1 Publications Verification	AMPK	Metabolic Disease Cancer
COH-SR4 is an *AMPK* activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders .

HY-12357S

Bempedoic acid-d5 ETC-1002-d₅; ESP-55016-d₅	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

HY-117623

PF-06685249 PF-249	AMPK	Metabolic Disease
PF-06685249 (PF-249) is a potent and orally active allosteric *AMPK* activator with an EC₅₀ of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research .

HY-12357

Bempedoic acid 5+ Cited Publications ETC-1002; ESP-55016	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates *AMPK* .

HY-103238

RSVA405	AMPK STAT Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology
RSVA405 is a potent, orally active activator of *AMPK, with an EC₅₀* of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity .

HY-103683

PF-06409577

AMPK Metabolic Disease

PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC₅₀ of 7 nM.

PF-06409577	AMPK	Metabolic Disease
PF-06409577 is a potent and selective allosteric activator of *AMPK* α1β1γ1 isoform with an EC₅₀ of 7 nM.

HY-112233

O-304 3 Publications Verification	AMPK	Cardiovascular Disease Metabolic Disease
O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications .

HY-B0923

Danthron 1 Publications Verification Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone	AMPK Autophagy Bacterial Virus Protease	Cancer
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating *AMPK*.

HY-100548

GSK621 2 Publications Verification
GSK621 is a specific *AMPK* activator, with IC₅₀ values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation .

HY-131958

D942

AMPK Cancer

D942 is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, D942 inhibits cell growth .

HY-N6258

Kahweol	AMPK Apoptosis	Metabolic Disease
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6913

3α-Hydroxymogrol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	AMPK
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent *AMPK* activator, and enhances AMPK phosphorylation .

HY-N2312

Mogrol 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Cancer	ERK STAT
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating *AMPK* signaling.

HY-N11924

Foenumoside B	Triterpenes Structural Classification Terpenoids Source classification Lysimachia foenum-graecum Hance Plants Primulaceae	AMPK PPAR
Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum. Foenumoside B activates *AMPK* signaling, inhibits PPARγ-induced adipogenesis, and shifts lipid metabolism toward lipolysis. Foenumoside B can be used in the study of obesity and obesity-related metabolic diseases .

HY-N6077

Thalidezine	Structural Classification Alkaloids Source classification Nelumbo nucifera Gaertn. Plants Nymphaeaceae Alkaloid Dimers	Others
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .

HY-N3425

Kazinol U	Flavonoids other families Classification of Application Fields Flavanols Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	AMPK
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-N6971

Cimiracemoside C Cimicifugoside M	Triterpenes Classification of Application Fields Terpenoids Source classification Ranunculaceae Metabolic Disease Plants Cimicifuga foetida Linn. Disease Research Fields	AMPK
Cimiracemoside C is an active component of Cimicifuga racemosa, activates *AMPK*, has the potential activity against diabetes .

HY-B0923

Danthron 1 Publications Verification Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	AMPK Autophagy Bacterial Virus Protease
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating *AMPK*.

HY-N6258

Kahweol	other families Classification of Application Fields Terpenoids Source classification Rubiaceae Metabolic Disease Diterpenoids Plants Disease Research Fields Coffea arabica L.	AMPK Apoptosis
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-134356

AICA-riboside, 5′-phosphate AICAR-5'-MP	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
AICA-riboside, 5′-phosphate (AICAR-5'-MP) is a 5'-phosphorylated analogue of AICAR. AICAR is an adenosine analog and a AMPK activator. .

HY-13417A

AICAR phosphate Maximum Cited Publications 121 Publications Verification Acadesine phosphate; AICA Riboside phosphate	Alkaloids Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Cancer	AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a *AMPK* activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

HY-13417

AICAR Maximum Cited Publications 121 Publications Verification Acadesine; AICA Riboside	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-N5083

Saponarin 1 Publications Verification	Flavonoids Classification of Application Fields Flavones Dipsacaceae Dipsacus sativus (Linn.) Honck. Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Others
Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities. Saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake .

HY-N10093

Chamaejasmine Chamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis AMPK Autophagy Reactive Oxygen Species
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of *AMPK/mTOR* signal pathway .

HY-112108

Chitosan oligosaccharide 4 Publications Verification COS	Structural Classification Polysaccharides Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Cancer	AMPK Endogenous Metabolite
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates *AMPK* and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.

HY-N3005

Britannin 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy
Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin induces apoptosis and autophagy by activating AMPK regulated by ROS in liver cancer cells. Britannin has anti-proliferative and anti-inflammatory activities .

HY-N12386

SIRT1 activator 1	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Marine natural products Marine microorganism	Sirtuin
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing SIRT1 expression levels and balancing the AMPK/Akt signaling pathway .

HY-N5018

Nepodin Musizin	Infection Rumex crispus Linn. Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants Disease Research Fields	Parasite AMPK
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N0592

Demethyleneberberine	Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	NF-κB AMPK
Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a *AMPK* activator for treating non-alcoholic fatty liver disease (NAFLD) .

HY-N3426

Kazinol B	other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	NO Synthase Akt AMPK
Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research .

HY-N0592A

Demethyleneberberine chloride	Structural Classification Alkaloids Phellodendron amurense Rupr. Source classification Rutaceae Phenols Polyphenols Plants	NF-κB AMPK
Demethyleneberberine chloride is a natural mitochondria-targeted antioxidant. Demethyleneberberine chloride alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine chloride could serve as a *AMPK* activator for researching non-alcoholic fatty liver disease (NAFLD) .

HY-N7676

Marein	Cardiovascular Disease Flavonoids Chalcones other families Classification of Application Fields Neurological Disease Source classification Phenols Polyphenols Plants Disease Research Fields	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

HY-W017212

Methyl cinnamate Methyl 3-phenylpropenoate	Microorganisms Classification of Application Fields Simple Phenylpropanols Source classification Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC.	Tyrosinase Bacterial AMPK
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N0385

Gomisin J 3 Publications Verification	Cardiovascular Disease Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	AMPK Calcium Channel
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity . Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca ²⁺/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease .

HY-N2447

Amarogentin 2 Publications Verification	Structural Classification Gentiana scabra Bunge Iridoids Classification of Application Fields Terpenoids Source classification Gentianaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	AMPK Apoptosis
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating *AMPK* .

HY-N0930B

Galegine hydrochloride	Alkaloids Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Disease Research Fields Galega officinalis Linn.	AMPK Bacterial
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates *AMPK* in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .

HY-13755

Sulforaphane 30+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

Cat. No.	Product Name	Chemical Structure

HY-12357S2

Bempedoic acid-d4
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

HY-110228

Metformin-d6 hydrochloride
Metformin-d₆ (hydrochloride)e is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy[1].

HY-12357S

Bempedoic acid-d5
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

HY-16397AS

Phenformin-d5 hydrochloride
Phenformin-d₅ (hydrochloride) is the deuterium labeled Phenformin hydrochloride. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity[1][2].

HY-B1221S

Flufenamic acid-d4

Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B1221S1

Flufenamic acid-13C6

Flufenamic acid- ¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B2099S

Buformin-d9 hydrochloride
Buformin-d₉ (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1].

HY-13417S

AICAR-13C2,15N
AICAR- ¹³C₂, ¹⁵N (Acadesine- ¹³C₂, ¹⁵N; AICA Riboside- ¹³C₂, ¹⁵N)is the ¹³C and ¹⁵N labeledAICAR(HY-13417) . AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-N8016S2

Nonanal-d2

Nonanal-d₂ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

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